Heterocyclylcarbonylamino, alkoxycarbonylamino, alkoxyimino,Īlkylsulfonylamino, arylsulfonylamino, formyl, alkylcarbonyl,Īrylcarbonyl, heterocyclylcarbonyl, cycloalkylcarbonyl, aminocarbonyl,Īlkylaminocarbonyl, dialkylaminocarbonyl, arylaminocarbonyl,Īlkylsulfonyl, arylsulfonyl, alkylaminosulfonyl, arylthio andĪlkylthio R 2 is a group selected from -NR''R''', -N(OH)R'', -OR'' Heterocyclylalkyloxy, methylenedioxy, alkylcarbonyloxy, arylcarbonyloxy,Ĭarboxy, alkoxycarbonyl, alkoxycarbonylalkyl, aryloxycarbonyl,Ĭycloalkyloxycarbonyl, amino, aminoalkyl, alkylaminoalkyl,Īlkylaminoalkyloxy, ureido, alkylamino, dialkylamino, arylamino,ĭiarylamino, formylamino, alkylcarbonylamino, arylcarbonylamino, Polyfluorinated alkoxy, aryloxy, arylalkyloxy, heterocyclyloxy, Hydroxyalkyl, aryl, arylalkyl, heterocyclyl, heterocyclylalkyl,Ĭycloalkyl, alkylaryl, alkylheterocyclyl, hydroxy, alkoxy, Groups (═O), cyano, azido, alkyl, polyfluorinated alkyl,
Analytical data were processed using the masslynx software free#
Heterocyclyl or heterocyclylalkyl or, in formula (Ib), R 1 is aĭivalent -(CH2)n-NH- group being linked to R 2, wherein n is 2 orģ wherein R 1 is optionally substituted in any of its free positionsīy one or more groups independently selected from: halogen, nitro, oxo Optionally substituted group selected from straight or branchedĬ 1-C 6 alkyl, C 3-C 6 cycloalkyl, aryl, arylalkyl, Ring as per formulae (Ia) or (Ib), represents a hydrogen atom or an Or S R 1, bonded to any one of the nitrogen atoms of the pyrazole Group optionally containing one additional heteroatom selected among N, O Heterocyclylalkyl or, together with the nitrogen atom to which they areīonded, R and R' may form a 5 to 6 membered heteroaryl or heterocyclyl Substituted group selected from straight or branched C 1-C 6Īlkyl, C 3-C 6 cycloalkyl, aryl, arylalkyl, heterocyclyl, S- or -SO 2-, wherein R' is hydrogen or an optionally Or branched C 1-C 6 alkyl, C 3-C 10 cycloalkyl, aryl,Īrylalkyl, heterocyclyl or heterocyclylalkyl X is a single bond or aĭivalent radical selected from -NR'-, -CONR'-, -NH-CO-NH-, -O-, Hydrogen or an optionally substituted group selected from amino, straight Mammal in need thereof an effective amount of a pyrazolo-quinazolineĭerivative represented by formula (Ia) or (Ib) #STR00522# whereinR is A method for treating cell proliferative disorders caused by and/orĪssociated with an altered protein kinase activity, by administering to a The treatment of diseases associated with a disregulated protein kinaseġ2. Their preparation and pharmaceutical compositions comprising them areĭisclosed the compounds of the invention may be useful, in therapy, in Specification, and pharmaceutically acceptable salts thereof, process for Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the Gabriella Traquandi (Milan, IT) Gabriella Traquandi (Milan, IT) Maria Gabriella Brasca (Cusago (milan), IT) Roberto D'Alessio (Milan, IT) Paolo Polucci (Milan, IT) Fulvia Roletto (Milan, IT) Anna Vulpetti (Milan, IT) Paolo Pevarello (Pavia, IT) Paolo Pevarello (Pavia, IT) Achille Panzeri (Merate (lc), IT) Achille Panzeri (Merate (lc), IT) Francesca Quartieri (Arona (no), IT) Ron Ferguson (Casale Litta (va), IT) Paola Vianello (Milan, IT) Daniele Fancelli (Milan, IT)Ĭlass name: Heterocyclic carbon compounds containing a hetero ring having chalcogen (i.e., o,s,se or te) or nitrogen as the only ring hetero atoms doai hetero ring is seven-membered consisting of two nitrogens and five carbon atoms polycyclo ring system having the seven-membered hetero ring as one of the cyclosĭaniele Fancelli Paolo Pevarello Gabriella Traquandi Maria Gabriella Brasca Roberto D'Alessio Paolo Polucci Fulvia Roletto Anna Vulpetti Achille Panzeri Francesca Quartieri Ron Ferguson Paola Vianello Patent application title: Pyrazolo-Quinazoline Derivatives, Process for Their Preparation and Their Use as Kinase Inhibitors
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